Polynucleotides Therapy



Procedure Time

30 min

Recovery Time


Result Duration

Up to 12 months

Skin Rejuvenation With Polynucleotides

Polynucleotide therapy is an advanced regenerative treatment that revitalises and rejuvenates your skin. Using purified polynucleotide molecules, typically derived from salmon DNA, this treatment stimulates natural collagen and elastin production, leading to firmer, smoother and more youthful-looking skin.

Ideal for reducing visible signs of ageing, this minimally invasive procedure offers a natural alternative to traditional fillers. You will also experience visible improvements within a few weeks, and with lasting results.

If you would like to book a consultation, we are open from 10.00 am – 8.00 pm Monday to Friday.

The Procedure

Prior To Treatment

Avoid alcohol and anti-inflammatory medications 24 hours before treatment. Please inform your practitioner of any allergies, medical conditions, or medications you are currently taking during your initial consultation.


After a detailed consultation, the target area is cleansed to create a sterile environment. A topical numbing cream is then applied to minimise discomfort. The polynucleotide solution is carefully injected into the skin using fine needles or cannulas, with a focus on areas that require rejuvenation. Our skilled practitioner will ensure the procedure is comfortable and effective, adjusting their technique to your unique skin needs.

After Treatment

Post-treatment, it’s common to experience some mild redness or swelling, which typically subsides within a few hours. We advise against touching the treated area for a few hours post-procedure to avoid irritation or infection. Avoid strenuous activities and exposure to extreme temperatures for 24 hours. While makeup can be applied after 12 hours, it’s recommended to use gentle, non-irritating products initially.

What To Expect

The polynucleotide treatment is generally painless, though some patients may feel a mild tingling sensation during the injections. The entire process is quick, usually taking about 30 minutes, and you can return to your normal activities shortly afterward. Initial improvements in skin texture and appearance can be seen within a few weeks, with continuing enhancements over time.

Polynucleotide Skin Boosters

The Results

  • Improved skin texture
  • Reduction in fine lines & wrinkles
  • Enhanced skin hydration
  • Boosted collagen & elastin production
  • Reduced appearance of skin imperfections
  • Overall youthful & rejuvenated skin appearance


Sam Kavanagh
Sam Kavanagh
Cannot rate this clinic highly enough. From initial booking and greeting from Carly who is always so lovely and accommodating, through to the treatment with Flavio. I wouldn’t trust anyone else with my face. He takes time and pride in his procedures. He makes you feel so special as a patient, he shares advice, he makes you feel safe and talks through everything with you. You leave feeling so confident in your appearance. Flavio’s work is unmatched, truly an artist and a magician.
hema soneji
hema soneji
Oh my word, what an incredibly efficient and friendly place. Forgot my B12 while travelling and I was sorted within a day. Staff are just incredible
Olivia Davies
Olivia Davies
Lovely welcoming clinic,Carly and Marina are fabulous, and I always feel like I am given the best service. I will be back for more treatments soon
I had a fabulous deep cleanse facial by Marina and it was spectacular. Amazing results and just what I needed at the end of a holiday! I’ve been to the clinic on a few occasions for this facial and each time it has been the best! It is the only clinic I will go to for a deep cleanse facial as it has demonstrated better results than any other clinic I’ve been to. Marina did my first ever facial at CF so I was thrilled to have another appointment with her! I really appreciated the time and care she put into my facial. I love how the extraction process doesn’t cause much redness, so when you are leaving the clinic your face isn’t blotchy or painful.
Jason Molloy
Jason Molloy
I’ve been coming to clinica Flore for a few years now and I honestly couldn’t recommended them enough. Always a warm welcome from the team Carly and Marina. The treatment is thoroughly professional and sorts out my chronic rosacea everytime, it’s a 10 out of 10 from me.
Omphile mabo
Omphile mabo
Before going in for my HIFU treatment I did some reading about the procedure, particularly about the side effects. One that had me a bit worried was being blotchy and red as I do have sensitive skin. However, Flavio was so gentle that I didn’t experience any redness after the treatment or pain during the procedure. Their staff is so friendly from the minute you call them to book an appointment to them performing the procedure. They update you with every step of the process so that you are aware of what they are doing to your face. I highly recommend their services they have indeed impressed me and I can’t wait for my next appointment with them. #HappyClient
Franko Briseno
Franko Briseno
I have been to other clinics and it is the first time the staff has been amazing, they showed they are actually passionate for what they do and they do care for the patients. I am over the moon with the treatments I received, I can say I’ve got incredible results. Definitely going back to Fiore for future treatments, and highly recommend it. Thank you so much Flavio, truly appreciate your commitment!
Great combination of the new and improved HIFU and new skin pen with ultrasound! Both treatments combined have massively improved the skin texture and lifting of facial contours, not even 24 downtime and virtually painless in my case, loved it! Would definitely recommend this combo or even as separate treatments as I did see big improvements on each session! Also the clinic is always at such high standards and always immaculately presented! Thank you, will be back!


Is Polynucleotide Therapy safe?

Yes, it’s a safe treatment derived from natural sources, such as salmon DNA, and is extensively purified for medical use. Side effects are minimal and temporary.

Initial improvements can be seen within a few weeks, with optimal results visible after a complete treatment course.

Minor swelling, redness, or bruising at the injection site, which typically subsides within 48 hours.

Yes, it complements various treatments, such as microneedling or radiofrequency, for enhanced results.

Avoid exfoliants and retinoids for a few days post-treatment. Additionally, ensure you use gentle, hydrating products to support healing.

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