Advanced Microneedling

Medical microneedling with PDRN, Niacinamide & LED Diode Mask

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Price
£295

Recovery Time

24-48 hours

Price: £295
Recovery Time: 24-48 hours

A results‑driven approach to brighter, healthier skin

Your skin deserves more than a surface-level fix. Over time, dullness, fine lines, and uneven texture can make it look tired, even when you’re not. You don’t need drastic measures. You need a treatment that works from the inside out.

Our medical-grade microneedling with PDRN and niacinamide is exactly that. This advanced protocol combines the precision of medical microneedling with the restorative benefits of PDRN (a bio‑identical DNA fragment) and niacinamide (vitamin B3), then finishes with an LED mask to calm and accelerate recovery.

How it works

Medical-grade microneedling creates thousands of microscopic channels in the skin. This triggers your body’s natural repair process, producing fresh collagen and elastin.

PDRN (polydeoxyribonucleotide) is a bio‑identical DNA fragment that stimulates fibroblast activity, promoting tissue regeneration and reducing inflammation. When infused via microneedling, it helps repair and rejuvenate from within.

Niacinamide (vitamin B3) soothes inflammation, evens skin tone, and strengthens the skin barrier, perfect for brightening and calming.

LED diode mask uses specific wavelengths (red and near‑infrared) to reduce redness, accelerate healing, and boost collagen production. It’s the ideal finishing touch for PDRN microneedling.

Think of it as a three‑step system: microneedling prepares, PDRN + niacinamide repairs and brightens, and LED locks it all in for faster results with less downtime.

The Procedure

  • Avoid retinols, exfoliating acids, and strong vitamin C for 3 days beforehand.
  • Do not take anti‑inflammatory medications (ibuprofen, aspirin) for 48 hours unless medically necessary.
  • Arrive with clean, makeup‑free skin.
  • Not suitable if you are pregnant, breastfeeding, or have active skin infections/cold sores in the treatment area.
  • Cleanse & numb: A topical anaesthetic is applied for comfort (20 minutes).
  • Medical grade microneedling: A sterile, fine‑needle pen glides over the skin, creating controlled micro‑injuries.
  • PDRN & niacinamide infusion: The serum is massaged deeply into the microchannels. This is the core of PDRN microneedling.
  • LED mask: A 15–20 minute LED session to calm redness, reduce inflammation, and enhance healing.
  • A hydrating mask is applied, then replaced with moisturiser and SPF application.
  • Do not touch or wash your face for 6 hours.
  • Avoid makeup, saunas, swimming, and intense exercise for 24 hours.
  • Use only gentle, non‑active skincare (no acids, retinols, or exfoliants) for 48 hours.
  • Apply SPF 30+ daily – the new skin is vulnerable to UV damage.

Sensation during treatment: Mild prickling and warmth, even with numbing cream. Most clients describe PDRN microneedling as “very tolerable”, similar to light sandpaper gliding over the skin. The LED mask feels warm and relaxing.

Your skin will look and feel like a mild sunburn, red, warm, and slightly tight. This is normal and a sign that the repair process has started.

 

Prior To Treatment

  • Avoid retinols, exfoliating acids, and strong vitamin C for 3 days beforehand.
  • Do not take anti‑inflammatory medications (ibuprofen, aspirin) for 48 hours unless medically necessary.
  • Arrive with clean, makeup‑free skin.
  • Not suitable if you are pregnant, breastfeeding, or have active skin infections/cold sores in the treatment area.

Treatment

  • Cleanse & numb: A topical anaesthetic is applied for comfort (20 minutes).
  • Medical grade microneedling: A sterile, fine‑needle pen glides over the skin, creating controlled micro‑injuries.
  • PDRN & niacinamide infusion: The serum is massaged deeply into the microchannels. This is the core of PDRN microneedling.
  • LED mask: A 15–20 minute LED session to calm redness, reduce inflammation, and enhance healing.
  • A hydrating mask is applied, then replaced with moisturiser and SPF application.

After Treatment

  • Do not touch or wash your face for 6 hours.
  • Avoid makeup, saunas, swimming, and intense exercise for 24 hours.
  • Use only gentle, non‑active skincare (no acids, retinols, or exfoliants) for 48 hours.
  • Apply SPF 30+ daily – the new skin is vulnerable to UV damage.

What To Expect

Sensation during treatment: Mild prickling and warmth, even with numbing cream. Most clients describe PDRN microneedling as “very tolerable”, similar to light sandpaper gliding over the skin. The LED mask feels warm and relaxing.

Your skin will look and feel like a mild sunburn, red, warm, and slightly tight. This is normal and a sign that the repair process has started.

 

RF Microneedling

The Results

  • Brighter, more even skin tone: niacinamide tackles dullness and pigmentation
  • Smoother texture: rough patches and fine lines soften
  • Deep hydration that lasts for weeks
  • Natural, healthy glow without looking “overdone”
  • Progressive regeneration yields the best results after 2–3 sessions of microneedling with PDRN.

Microneedling Cost

Advanced Microneedling

£295

Microneeding with Exosomes

£295

RF Microneedling

£350

Advanced Microneedling

£295

Microneeding with Exosomes

£295

RF Microneedling

£350

testimonials

EXCELLENT
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Based on 108 reviews
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Sam Kavanagh
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Cannot rate this clinic highly enough. From initial booking and greeting from Carly who is always so lovely and accommodating, through to the treatment with Flavio. I wouldn’t trust anyone else with my face. He takes time and pride in his procedures. He makes you feel so special as a patient, he shares advice, he makes you feel safe and talks through everything with you. You leave feeling so confident in your appearance. Flavio’s work is unmatched, truly an artist and a magician.
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hema soneji
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Oh my word, what an incredibly efficient and friendly place. Forgot my B12 while travelling and I was sorted within a day. Staff are just incredible
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Olivia Davies
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Lovely welcoming clinic,Carly and Marina are fabulous, and I always feel like I am given the best service. I will be back for more treatments soon
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Sarah profile picture
Sarah
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I had a fabulous deep cleanse facial by Marina and it was spectacular. Amazing results and just what I needed at the end of a holiday! I’ve been to the clinic on a few occasions for this facial and each time it has been the best! It is the only clinic I will go to for a deep cleanse facial as it has demonstrated better results than any other clinic I’ve been to. Marina did my first ever facial at CF so I was thrilled to have another appointment with her! I really appreciated the time and care she put into my facial. I love how the extraction process doesn’t cause much redness, so when you are leaving the clinic your face isn’t blotchy or painful.
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Jason Molloy
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I’ve been coming to clinica Flore for a few years now and I honestly couldn’t recommended them enough. Always a warm welcome from the team Carly and Marina. The treatment is thoroughly professional and sorts out my chronic rosacea everytime, it’s a 10 out of 10 from me.
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Omphile mabo
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Before going in for my HIFU treatment I did some reading about the procedure, particularly about the side effects. One that had me a bit worried was being blotchy and red as I do have sensitive skin. However, Flavio was so gentle that I didn’t experience any redness after the treatment or pain during the procedure. Their staff is so friendly from the minute you call them to book an appointment to them performing the procedure. They update you with every step of the process so that you are aware of what they are doing to your face. I highly recommend their services they have indeed impressed me and I can’t wait for my next appointment with them. #HappyClient
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Franko Briseno
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I have been to other clinics and it is the first time the staff has been amazing, they showed they are actually passionate for what they do and they do care for the patients. I am over the moon with the treatments I received, I can say I’ve got incredible results. Definitely going back to Fiore for future treatments, and highly recommend it. Thank you so much Flavio, truly appreciate your commitment!
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Fabri profile picture
Fabri
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Great combination of the new and improved HIFU and new skin pen with ultrasound! Both treatments combined have massively improved the skin texture and lifting of facial contours, not even 24 downtime and virtually painless in my case, loved it! Would definitely recommend this combo or even as separate treatments as I did see big improvements on each session! Also the clinic is always at such high standards and always immaculately presented! Thank you, will be back!
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Awards

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FAQs

Is PDRN microneedling painful?

Most clients rate the discomfort as 2–3 out of 10. The numbing cream helps significantly. The LED mask is completely painless – many clients find it relaxing.

For best results, a course of 3-6 sessions, spaced 4–6 weeks apart. Maintenance sessions, once or twice a year, keep the brightness and texture.

You’ll notice a “glass skin” glow after 5–7 days. Collagen remodelling continues for up to 3 months, so texture and firmness improve progressively.

  • Active acne, cold sores, or skin infections in the treatment area
  • Pregnancy or breastfeeding
  • Blood clotting disorders or on blood thinners (warfarin, rivaroxaban)
  • Recent (within 4 weeks) facial surgery, fillers, or chemical peels in the same area

Yes, it already includes an LED treatment, but you could add a hydrating facial 2 weeks later. Avoid same‑day lasers or deep peels.

We are located a 4-minute walk from Tottenham Court Road tube station and a 9-minute walk from Holborn station.

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